Yikuphi Ukuthwebula Okuphumelelayo Kakhulu Ekutholeni Ukuphindaphinda Kwe-Biochemical Komdlavuza We-Prostate: I-PET/CT noma i-mpMRI?

Ngokusho kokuhlaziywa kwe-meta kwakamuva, i-positron emission tomography/computed tomography (PET/CT) kanye ne-multi-parameter magnetic resonance imaging (mpMRI) zinikeza amazinga afanayo okuthola umdlavuza we-prostate (PCa) ophinde uvele.

Abacwaningi bathole ukuthi i-prostate specific membrane antigen (PSMA) PET/CT yayinezinga lokutholakala eliphelele elingamaphesenti angu-69 lokuphinda kuvele umdlavuza we-prostate, uma kuqhathaniswa namaphesenti angu-70 e-mpMRI.

"Ngokubuyela emuva kwe-biochemical, zombili izindlela ziyasebenza. Imiphumela yethu ikhombisa ukuthi akukho mehluko obalulekile ku-DR iyonke (izinga lokutholakala) phakathi kwezindlela ezimbili zokuthwebula izithombe, futhi i-mpMRI ingabizi kakhulu ngenkathi igcina i-DR efanayo," kubhala umlobi osebenzisana nocwaningo uL. Xu, oxhumene neSikole Sezokwelapha. I-Hunan University of Traditional Chinese Medicine, eHunan, eShayina kanye nozakwabo.

Ngokuphindelela kwe-PCa yendawo, abalobi bocwaningo baphawule ukuthi i-DR On mpMRI yayiphezulu ngo-10% (62% vs. 52%). Abacwaningi bathole nokuthi i-PSMA PET/CT ibonise ukuthuthuka okungu-18% ku-DR When diagnosing lymph node metastasis (50% kanye no-32%, ngokulandelana). Kodwa-ke, akukho okutholakele okwakubalulekile ngokwezibalo, kusho ababhali bocwaningo.

Abacwaningi bakholelwa ukuthi ukuzwela okuphezulu kanye nokucacisa kunganikeza i-PSMA PET/CT ithuba lokuhlola i-PCa kanye nokuthola izilonda ezincane, kodwa futhi bayavuma ukuthi ukutholakala kwendlela kuyinkinga. I-MRI yamapharamitha amaningi ingaba usizo ekuxilongeni ukuphinda kwesifo endaweni kanye ne-PCa ebalulekile emitholampilo, kodwa abalobi bocwaningo bayavuma ukuthi ukungafani kwababukeli kungaba yinkinga nge-mpMRI.

Kodwa-ke, imiphumela iyonke yokuhlaziywa kwe-meta isikisela ukuthi zombili lezi zindlela zinendima ekuxilongweni kwe-PCa BCR, futhi zikhomba ezifundweni ezizayo ezinganikeza ukucaca okukhulu kulokhu.

UXu kanye nozakwabo bagcizelele umthelela omkhulu wemiphumela yocwaningo ekusebenzeni kwezokwelapha. Baveze ukuthi amakhono okuxilonga afanayo e-PSMA PET/CT kanye ne-mpMRI abonisa ukusebenza kahle kwazo zombili izindlela ekutholeni i-BCR ezigulini ze-PCa. Kodwa-ke, bagcizelele isidingo socwaningo olwengeziwe ukuze kuhlolwe ukuthi lawa masu okuthwebula izithombe angabizi kangakanani, afinyeleleka kalula, kanye nokusebenza kahle kangakanani.

Lapho bexoxa ngemikhawulo yocwaningo, abalobi bavumile ukuthi isampula encane yeziguli ezingu-290 yayiwumphumela wokugxila kwabo ekuhlaziyeni izifundo zokuqhathanisa ukuze bathole i-BCR ngaphakathi kwamaqembu eziguli afanayo. Baphinde baphakamisa ukuthi kungenzeka ukuthi kube nokubandlulula emiphumeleni ngenxa yezinqubo ezahlukene zokuthatha izithombe kanye nezici zesiguli kuzo zonke izifundo eziyisithupha abazibukezile.

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Ngokuthuthuka kobuchwepheshe bokuthwebula izithombe zezokwelapha, kuphuma izinkampani eziningi ezingahlinzeka ngemikhiqizo yokuthwebula izithombe, njengezijovo kanye nesirinji.I-LnkMedubuchwepheshe bezokwelapha bungenye yazo. Sihlinzeka ngephothifoliyo ephelele yemikhiqizo yokuxilonga esekelayo:Umjovo owodwa we-CT，Umjovo wekhanda eliphindwe kabili we-CT,Umjovo we-MRIfuthiUmjovo we-DSA ocindezela kakhuluZisebenza kahle nezinhlobo ezahlukene ze-CT/MRI scanner ezifana ne-GE, i-Philips, i-Siemens. Ngaphandle kwe-injector, siphinde sinikeze i-syringe kanye ne-tube engasetshenziswa emikhakheni ehlukene ye-injector ehlanganisa i-Medrad/Bayer, i-Mallinckrodt/Guerbet, i-Nemoto, i-Medtron, ne-Ulrich.
Lokhu okulandelayo yizici zethu eziyinhloko: izikhathi zokulethwa okusheshayo; Iziqu eziphelele zesitifiketi, iminyaka eminingi yesipiliyoni sokuthumela ngaphandle, inqubo yokuhlola ikhwalithi ephelele, imikhiqizo esebenza ngokugcwele, siyakwamukela ngemfudumalo umbuzo wakho.