Ukuthwebula izithombe zezokwelapha kuvame ukusiza ukuhlonza ngempumelelo nokwelapha ukukhula komdlavuza. Ikakhulukazi, i-magnetic resonance imaging (MRI) isetshenziswa kabanzi ngenxa yokulungiswa kwayo okuphezulu, ikakhulukazi ngama-agent ahlukile.
Ucwaningo olusha olushicilelwe kujenali i-Advanced Science lubika nge-ejenti entsha yokuzigoqa ye-nanoscale engase isize ukubona ngeso lengqondo izimila ngokuningiliziwe nge-MRI.
Kuyini umehlukoabezindaba?
Imidiya yokuqhathanisa (eyaziwa nangokuthi imidiya ehlukile) ingamakhemikhali ajovwe (noma athathwe) ezicutshini zomuntu noma ezithweni ukuze kuthuthukiswe ukubhekwa kwesithombe. Lawa malungiselelo aminyene noma aphansi kunethishu ezungezile, okwenza umehluko osetshenziselwa ukubonisa izithombe ngezinye izisetshenziswa. Isibonelo, amalungiselelo e-iodine, i-barium sulfate, njll. ngokuvamile asetshenziselwa ukubhekwa kwe-X-ray. Ijovwa emithanjeni yegazi yesiguli ngesirinji yokuqhathanisa nengcindezi ephezulu.
Ku-nanoscale, ama-molecule aphikelela egazini isikhathi eside futhi angangena ezimila eziqinile ngaphandle kokuyenga izindlela zokubalekela amasosha omzimba athile. Ama-molecular complexes amaningana asekelwe kuma-nanomolecules acutshungulwe njengabathwali abangaba khona be-CA baba izimila.
Lawa ma-agent ahlukile we-nanoscale (NCAs) kufanele asatshalaliswe ngendlela efanele phakathi kwegazi nezicubu ezithakaselwayo ukuze kuncishiswe umsindo wangemuva futhi kuzuzwe isilinganiso esiphezulu sesignali-to-noise (S/N). Emazingeni aphezulu, i-NCA iphikelela egazini isikhathi eside, ngaleyo ndlela ikhulise ingozi ye-fibrosis ebanzi ngenxa yokukhululwa kwe-gadolinium ions eyinkimbinkimbi.
Ngeshwa, ama-NCA amaningi asetshenziswayo njengamanje aqukethe inhlanganisela yezinhlobo eziningana zama-molecule. Ngaphansi komkhawulo othile, lawa ma-micelles noma ama-aggregate athambekele ekuhlukaniseni, futhi umphumela walo mcimbi awucacile.
Lolu cwaningo oluphefumulelwe kuma-nanoscale macromolecules azigoqayo angenawo ama-critical dissociation threshold. Lokhu kuhlanganisa umgogodla onamafutha kanye nongqimba lwangaphandle oluncibilikayo oluphinde lukhawulele ukunyakaza kwamayunithi ancibilikayo endaweni yokuxhumana. Lokhu kungase kube nomthelela kumapharamitha wokuphumuza amangqamuzana neminye imisebenzi engashintshwa ukuze kuthuthukiswe ukulethwa kwezidakamizwa kanye nezimpawu ezithile ku-vivo.
Imidiya yokuqhathanisa ivamise ukujovwa emzimbeni wesiguli ngomjovo wokungafani onomfutho ophezulu.I-LnkMed, umkhiqizi ochwepheshe ogxile ocwaningweni nasekuthuthukisweni kwezijovo zama-ejenti wokuqhathanisa nezinto ezisetshenziswayo ezisekelayo, uthengiseCT, I-MRI, futhiI-DSAama-injection ekhaya naphesheya futhi aqashelwe yimakethe emazweni amaningi. Imboni yethu ingahlinzeka ngakho konke ukusekelaizinto ezisetshenziswayookwamanje ethandwa ezibhedlela. Ifektri yethu inezinqubo eziqinile zokuhlola ikhwalithi yokukhiqizwa kwezimpahla, ukulethwa okusheshayo, kanye nenkonzo ephelele nephumelelayo yangemva kokuthengisa. Bonke abasebenzi beI-LnkMedngithemba ukubamba iqhaza okwengeziwe embonini ye-angiography esikhathini esizayo, ukuqhubeka nokudala imikhiqizo yekhwalithi ephezulu yamakhasimende, futhi unikeze ukunakekelwa kweziguli.
Ucwaningo lubonisani?
Indlela entsha yethulwa ku-NCA ethuthukisa isimo sokuphumula se-longitudinal sama-proton, esivumela ukuthi ikhiqize izithombe ezibukhali ekulayisheni okuphansi kakhulu kwe-gadolinium complexes. Ukulayisha okuphansi kunciphisa ubungozi bemiphumela emibi ngoba umthamo we-CA mncane.
Ngenxa yendawo ezigoqayo, i-SMDC ewumphumela inomgogodla ominyene nendawo eyinkimbinkimbi eminyene. Lokhu kukhulisa ukukhululeka njengoba ukunyakaza kwangaphakathi nesigaba esizungeze isixhumi esibonakalayo se-SMDC-Gd kungase kukhawulelwe.
Le NCA inganqwabelana ngaphakathi kwamathumba, okwenza kube nokwenzeka ukusebenzisa i-Gd neutron capture therapy ukwelapha izimila ngokuqondile nangempumelelo. Kuze kube manje, lokhu akukafinyelelwa ngokomtholampilo ngenxa yokuntuleka kokukhetha ukuletha i-157Gd kumathumba nokuyigcina isendaweni efanele. Isidingo sokujova imithamo ephezulu sihlotshaniswa nemiphumela emibi kanye nemiphumela emibi ngoba inani elikhulu le-gadolinium elizungeze isimila liyalivikela ekuchayekeni kwe-neutron.
I-nanoscale isekela ukuqoqwa okukhethiwe kokugxila kokwelapha kanye nokusatshalaliswa okuphelele kwezidakamizwa ngaphakathi kwamathumba. Ama-molecule amancane angaphuma kuma-capillaries, okuholela ekusebenzeni okuphezulu kwe-antitumor.
“Uma kubhekwa ukuthi ububanzi be-SMDC bungaphansi kuka-10 nm, esikutholile kungenzeka kusuke ekungeneni okujulile kwe-SMDC kumathumba, okusiza ukubalekela umphumela wokuvikela ama-neutron ashisayo kanye nokuqinisekisa ukusabalala okusebenzayo kwama-electron kanye nemisebe ye-gamma ngemva kokuchayeka kwe-neutron eshisayo.“
Uyini umthelela?
"Ingasekela ukuthuthukiswa kwama-SMDC athuthukisiwe ukuze kuhlonzwe kangcono isimila, ngisho nalapho kudingeka imijovo eminingi ye-MRI."
"Esikutholile kugqamisa amandla okulungisa i-NCA ngokuzihlela ngokwazo futhi kuphawule intuthuko enkulu ekusetshenzisweni kwe-NCA ekuxilongeni nasekulapheni umdlavuza."
Isikhathi sokuthumela: Dec-08-2023
