Ukuthwebula izithombe zezokwelapha kuvame ukusiza ekuxilongeni nasekuphatheni izimila zomdlavuza ngempumelelo. Ikakhulukazi, ukuthwebula izithombe ze-magnetic resonance (MRI) kusetshenziswa kabanzi ngenxa yekhwalithi yayo ephezulu, ikakhulukazi ngama-contrast agents.
Ucwaningo olusha olushicilelwe ephephabhukwini i-Advanced Science lubika nge-ejenti entsha yokuhlukanisa i-nanoscale ezigoqayo engasiza ekuboniseni amathumba ngokuningiliziwe nge-MRI.
Kuyini ukungafaniimidiya?
I-contrast media (eyaziwa nangokuthi i-contrast media) amakhemikhali afakwa (noma athathwe) ezicutshini noma ezithweni zomuntu ukuze kuthuthukiswe ukubuka isithombe. Lawa malungiselelo aminyene noma aphansi kunezicubu ezizungezile, okwenza i-contrast esetshenziselwa ukubonisa izithombe ngamadivayisi athile. Isibonelo, amalungiselelo e-iodine, i-barium sulfate, njll. avame ukusetshenziswa ekuhlolweni kwe-X-ray. Ifakwa emthanjeni wegazi wesiguli ngesirinji ye-contrast enomfutho ophezulu.
Ku-nanoscale, ama-molecule ahlala egazini isikhathi eside futhi angangena ezimila eziqinile ngaphandle kokubangela izindlela zokugwema amasosha omzimba eziqondene nesimila. Izinhlanganisela eziningana zama-molecule ezisekelwe kuma-nanomolecule ziye zafundwa njengabathwali be-CA abangase babe izimila.
Lawa ma-nanoscale contrast agents (ama-NCA) kumele asatshalaliswe kahle phakathi kwegazi nezicubu ezithandekayo ukuze kuncishiswe umsindo wangemuva futhi kufinyelelwe isilinganiso esiphezulu sesignali-kuya-kumsindo (S/N). Uma kugxilwe kakhulu, i-NCA ihlala egazini isikhathi eside, ngaleyo ndlela yandisa ingozi ye-fibrosis ebanzi ngenxa yokukhishwa kwama-ion e-gadolinium avela ku-complex.
Ngeshwa, ama-NCA amaningi asetshenziswa njengamanje aqukethe izinhlangano zezinhlobo eziningana ezahlukene zama-molecule. Ngaphansi komkhawulo othile, lawa ma-micell noma ama-aggregate avame ukuhlukana, futhi umphumela walesi senzakalo awucaci.
Lokhu kuphefumulele ucwaningo ngama-macromolecule e-nanoscale ezigoqayo angenazo imingcele ebalulekile yokuhlukaniswa. Lawa aqukethe umongo wamafutha kanye nengqimba yangaphandle encibilikayo ephinde ikhawulele ukuhamba kwamayunithi ancibilikayo phezu kobuso bokuxhumana. Lokhu kungathinta amapharamitha okuphumula kwama-molecule kanye neminye imisebenzi engasetshenziswa ukuthuthukisa ukulethwa kwezidakamizwa kanye nezakhiwo zokucacisa emzimbeni.
I-contrast media ivame ukufakwa emzimbeni wesiguli nge-contrast injector enomfutho ophezulu.I-LnkMed, umenzi ochwepheshe ogxile ocwaningweni nasekuthuthukisweni kwama-injector agent injector kanye nezinto ezisetshenziswayo ezisekelayo, uthengiseCT, I-MRI, futhiI-DSAama-injector ekhaya nakwamanye amazwe futhi aqashelwa yimakethe emazweni amaningi. Ifektri yethu ingahlinzeka ngakho konke okusekelayookudliwayookwamanje ithandwa ezibhedlela. Ifektri yethu inezinqubo eziqinile zokuhlola ikhwalithi yokukhiqizwa kwezimpahla, ukulethwa okusheshayo, kanye nensizakalo ephelele nephumelelayo ngemuva kokuthengisa. Bonke abasebenzi beI-LnkMedNgithemba ukuthi ngizobamba iqhaza kakhulu embonini ye-angiography esikhathini esizayo, ngiqhubeke nokudala imikhiqizo esezingeni eliphezulu yamakhasimende, futhi nginikeze ukunakekelwa kweziguli.
Ucwaningo lukhombisani?
Indlela entsha yethulwa ku-NCA ethuthukisa isimo sokuphumula eside sama-proton, okuvumela ukuthi ikhiqize izithombe ezibukhali kakhulu emithwalweni ephansi kakhulu yama-gadolinium complexes. Ukulayisha okuphansi kunciphisa ingozi yemiphumela emibi ngoba umthamo we-CA mncane kakhulu.
Ngenxa yesakhiwo esizigoqayo, i-SMDC ephumelayo inomgogodla ominyene kanye nendawo eyinkimbinkimbi egcwele abantu. Lokhu kwandisa ukukhululeka njengoba ukunyakaza kwangaphakathi nokwengxenye kuzungeze isikhombimsebenzisi se-SMDC-Gd kungavinjelwa.
Le NCA inganqwabelana ngaphakathi kwezimila, okwenza kube nokwenzeka ukusebenzisa ukwelashwa kokubamba i-Gd neutron ukwelapha izimila ngokuqondile nangokuphumelelayo. Kuze kube manje, lokhu akukafinyelelwa ngokwezokwelapha ngenxa yokuntuleka kokukhetha ukuletha i-157Gd ezimilaneni nokuzigcina zisezingeni elifanele. Isidingo sokufaka imithamo ephezulu sihlotshaniswa nemiphumela emibi kanye nemiphumela emibi ngoba inani elikhulu le-gadolinium elizungeze isimila lisivikela ekuvezweni yi-neutron.
I-nanoscale isekela ukuqongelela okukhethiwe kwamazinga okwelapha kanye nokusatshalaliswa okuhle kwemithi ngaphakathi kwamathumba. Ama-molecule amancane angaphuma kuma-capillary, okuholela ekusebenzeni okuphezulu kokulwa nomdlavuza.
"Njengoba ububanzi be-SMDC bungaphansi kuka-10 nm, okutholakele kwethu kungenzeka ukuthi kuvela ekungeneni okujulile kwe-SMDC ezimila, okusiza ukubalekela umphumela wokuvikela we-thermal neutrons nokuqinisekisa ukusabalala okuphumelelayo kwama-electron kanye nemisebe ye-gamma ngemva kokuvezwa yi-thermal neutron."
Uyini umthelela?
"Ingasekela ukuthuthukiswa kwama-SMDC alungiselelwe kahle ukuze kutholakale umdlavuza kangcono, noma ngabe kudingeka imijovo eminingi ye-MRI."
"Okutholakele kwethu kugqamisa amandla okulungisa i-NCA ngokuklama ama-molecule okuzigoqa futhi kuphawule intuthuko enkulu ekusetshenzisweni kwe-NCA ekuxilongweni nasekwelapheni umdlavuza."
Isikhathi sokuthunyelwe: Disemba-08-2023
