Ukuthuthukisa Ukunakekelwa Kwesiguli Nge-AI-based Attenuation Correction in PET Imaging

Ucwaningo olusha olunesihloko esithi “Utilizing Pix-2-Pix GAN for Deep Learning-based Whole-Body PSMA PET/CT Attenuation Correction” lusanda kushicilelwa kuVolumu 15 ye-Oncotarget ngoMeyi 7, 2024.

Ukuchayeka emisebeni evela ezifundweni ezilandelanayo ze-PET/CT ekulandeleni isiguli se-oncology kuyakhathaza. Kulolu phenyo lwakamuva, ithimba labacwaningi elihlanganisa u-Kevin C. Ma, Esther Mena, Liza Lindenberg, Nathan S. Lay, Phillip Eclarinal, Deborah E. Citrin, Peter A. Pinto, Bradford J. Wood, William L. Dahut, James L. Gulley, Ravi A. Madan, Peter L. Choyke, Ismail Baris Turkbey, no-Stephanie A. Harmon ovela ku-National Cancer Institute e-National Institutes of Health yethula ithuluzi le-artificial intelligence (AI). Leli thuluzi lihlose ukukhiqiza izithombe ze-PET (AC-PET) ezilungiswe ukuncishiswa kusuka ezithombeni ze-PET (NAC-PET) ezingalungisiwe, okungenzeka zinciphise isidingo samaskena e-CT anedosi eliphansi.

"Izithombe ze-PET ezikhiqizwe nge-Ai zinamandla omtholampilo okunciphisa isidingo sokulungiswa kwe-CT scan ngenkathi kugcinwa izimpawu zobuningi kanye nekhwalithi yesithombe ezigulini ezinomdlavuza wendlala yesinye."

Izindlela: I-algorithm yokufunda ejulile esekelwe ku-2D Pix-2-Pix generative adversarial network (GAN) architecture yasungulwa ngokusekelwe ezithombeni ezibhanqiwe ze-AC-PET ne-NAC-PET. I-18F-DCFPyL PSMA (i-Prostate-specific membrane antigen) Ucwaningo lwe-PET-CT lweziguli ze-302 ezinomdlavuza we-prostate lwahlukaniswa lwaba ukuqeqeshwa, ukuqinisekiswa, namaqembu okuhlola (n 183, 60, kanye ne-59, ngokulandelana). Imodeli yaqeqeshwa kusetshenziswa amasu amabili amisiwe: I-Standard Uptake Value (SUV) esuselwe kanye ne-SUV-NYUL. Ukuskena ukusebenza okuvundlile kwahlaziywa kusetshenziswa iphutha le-normalized mean square square (NMSE), mean absolute error (MAE), structural similarity index (SSIM) kanye ne-peak signal-to-noise ratio (PSNR). Udokotela wezokwelapha nge-nuclear kungenzeka ukuthi wenze ukuhlaziya kwezinga lezilonda endaweni ethakaselwayo. Izinkomba ze-SUV zihlolwe kusetshenziswa i-intra-group coefficient (ICC), i-repeability coefficient (RC), kanye namamodeli wemiphumela exubile yomugqa.

Imiphumela:Eqenjini lokuhlola elizimele, i-NMSE emaphakathi, i-MAE, i-SSIM, ne-PSNR bekungu-13.26%, 3.59%, 0.891, kanye no-26.82, ngokulandelana. I-ICC ye-SUVmax ne-SUVmean ibingu-0.88 no-0.89, okubonisa ukuhlobana okuqinile phakathi komaka bezithombe zangempela nabakhiqizwe be-AI. Izinto ezifana nendawo yesilonda, ukuminyana (amayunithi e-Hounsfield), nokuthathwa kwesilonda kutholwe ukuthi kunomthelela ephutheni elihlobene kumamethrikhi e-SUV akhiqiziwe (konke p <0.05).

“I-AC-PET ekhiqizwe imodeli ye-Pix-2-Pix GAN ibonisa amamethrikhi e-SUV aqondana eduze nezithombe zangempela. Izithombe ze-PET ezikhiqizwe yi-AI zibonisa amandla athembisayo omtholampilo okunciphisa isidingo samaskena e-CT ukuze kulungiswe ukuncipha ngenkathi kugcinwa izimpawu zobuningi nekhwalithi yesithombe.”

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Njengoba sonke sazi, ukuthuthukiswa kwemboni yezithombe zezokwelapha akunakuhlukaniswa nokuthuthukiswa kochungechunge lwemishini yezokwelapha - ama-ejenti e-agent ehlukile kanye nezinto ezisetshenziswayo ezisekelayo - ezisetshenziswa kakhulu kulo mkhakha. E-China, edume ngemboni yayo yokukhiqiza, kunabakhiqizi abaningi abadumile ekhaya naphesheya ngokukhiqizwa kwemishini yokuthwebula yezokwelapha, okuhlanganisa.I-LnkMed. Selokhu yasungulwa, i-LnkMed ibilokhu igxile emkhakheni wama-ejenti wokuqhathanisa nengcindezi ephezulu. Ithimba lonjiniyela be-LnkMed liholwa yi-Ph.D. unolwazi olungaphezu kweminyaka eyishumi futhi ubambe iqhaza ngokujulile ocwaningweni nasekuthuthukisweni. Ngaphansi kokuqondisa kwakhe, iCT umjovo wekhanda elilodwa,I-CT double head injector,Umjovo we-ejenti yokuqhathanisa ye-MRI, futhiUmjovo we-angiography wokucindezela okuphezulu kokungafaniaklanywe ngalezi zici: umzimba oqinile futhi ohlangene, isixhumi esibonakalayo esisebenzayo nesihlakaniphile, imisebenzi ephelele, ukuphepha okuphezulu, kanye nomklamo oqinile. Futhi singahlinzeka ngamasirinji namashubhu ahambisana nalezo zinhlobo ezidumile zamajovo e-CT,MRI,DSA Ngesimo sabo sengqondo esiqotho namandla ochwepheshe, bonke abasebenzi be-LnkMed bakumema ngobuqotho ukuthi nize nizohlola izimakethe ezengeziwe ndawonye.