Ukuthuthukisa Ukunakekelwa Kwesiguli Ngokulungiswa Kokunciphisa Okusekelwe ku-AI ku-PET Imaging

Ucwaningo olusha olunesihloko esithi “Using Pix-2-Pix GAN for Deep Learning-Based Whole-Body PSMA PET/CT Attenuation Correction” lusanda kushicilelwa kuMqulu 15 we-Oncotarget ngoMeyi 7, 2024.

Ukuvezwa kwemisebe okuvela ezifundweni ze-PET/CT ezilandelanayo ekulandelelweni kweziguli ze-oncology kuyakhathaza. Kulolu phenyo lwakamuva, ithimba labacwaningi elihlanganisa uKevin C. Ma, u-Esther Mena, uLiza Lindenberg, uNathan S. Lay, uPhillip Eclarinal, uDeborah E. Citrin, uPeter A. Pinto, uBradford J. Wood, uWilliam L. Dahut, uJames L. Gulley, uRavi A. Madan, uPeter L. Choyke, u-Ismail Baris Turkbey, kanye noStephanie A. Harmon abavela kwi-National Cancer Institute e-National Institutes of Health bethule ithuluzi lobuhlakani bokwenziwa (AI). Leli thuluzi lihlose ukukhiqiza izithombe ze-PET (AC-PET) ezilungisiwe ngokunciphisa ukuncipha kokukhanya kusuka ezithombeni ze-PET (NAC-PET) ezingalungisiwe ngokunciphisa ukuncipha kokukhanya, okungenzeka kunciphise isidingo sokuskena kwe-CT ngemithamo ephansi.

"Izithombe ze-PET ezikhiqizwe yi-Ai zinamandla okwelapha okunciphisa isidingo sokulungiswa kokunciphisa ukuqina kwezicubu kuma-CT scan ngenkathi kulondolozwa izimpawu zokulinganisa kanye nekhwalithi yesithombe seziguli ezinomdlavuza wendlala yesinye."

Izindlela: I-algorithm yokufunda okujulile esekelwe kusakhiwo senethiwekhi ephikisanayo yokukhiqiza ye-2D Pix-2-Pix (GAN) yathuthukiswa ngokusekelwe ezithombeni ze-AC-PET kanye ne-NAC-PET ezibhangqiwe. Ucwaningo lwe-PET-CT lwe-18F-DCFPyL PSMA (i-prostate-specific membrane antigen) lweziguli ezingu-302 ezinomdlavuza we-prostate lwahlukaniswa ngamaqembu okuqeqesha, ukuqinisekiswa, kanye nokuhlola (n 183, 60, kanye no-59, ngokulandelana). Imodeli yaqeqeshwa kusetshenziswa amasu amabili ajwayelekile: I-Standard Uptake Value (SUV) esekelwe kanye ne-SUV-NYUL esekelwe. Ukuskena ukusebenza okuvundlile kwahlolwa kusetshenziswa iphutha lesikwele elijwayelekile (NMSE), iphutha eliphelele eliphakathi (MAE), inkomba yokufana kwesakhiwo (SSIM) kanye nesilinganiso se-peak signal-to-noise (PSNR). Udokotela wezokwelapha ze-nuclear wenza ukuhlaziywa kwezinga lesilonda endaweni ethandwayo. Izinkomba ze-SUV zahlolwa kusetshenziswa i-intra-group correlation coefficient (ICC), i-repeatability coefficient (RC), kanye namamodeli e-linear mixed effects.

Imiphumela：Kuqembu lokuhlola elizimele, i-NMSE, i-MAE, i-SSIM, kanye ne-PSNR ephakathi nendawo yayingu-13.26%, 3.59%, 0.891, kanye no-26.82, ngokulandelana. I-ICC ye-SUVmax kanye ne-SUV mean yayingu-0.88 kanye no-0.89, okubonisa ubudlelwano obuqinile phakathi kwezimpawu zokuqala zesithombe ezikhiqizwa yi-AI kanye ne-AI. Izici ezifana nendawo yezilonda, ubuningi (amayunithi e-Hounsfield), kanye nokuthathwa kwezilonda kutholakale ukuthi kuthinta iphutha elihlobene kuma-metric e-SUV akhiqizwe (konke okungu-p < 0.05).

"I-AC-PET ekhiqizwe yimodeli ye-Pix-2-Pix GAN ikhombisa izibalo ze-SUV ezihambisana eduze nezithombe zokuqala. Izithombe ze-PET ezikhiqizwe yi-AI zibonisa amandla ezokwelapha athembisayo okunciphisa isidingo sokuskena kwe-CT ukuze kulungiswe ukuncishiswa kwesisindo ngenkathi kugcinwa izimpawu zobuningi kanye nekhwalithi yesithombe."

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Njengoba sonke sazi, intuthuko yemboni yezithombe zezokwelapha ayihlukaniseki ekuthuthukisweni kochungechunge lwemishini yezokwelapha - ama-injector agent injector kanye nezinto ezisetshenziswayo ezisekelayo - ezisetshenziswa kabanzi kulo mkhakha. EShayina, edume ngemboni yayo yokukhiqiza, kunabakhiqizi abaningi abadumile ekhaya nakwamanye amazwe ngokukhiqiza imishini yezithombe zezokwelapha, okuhlanganisaI-LnkMedKusukela yasungulwa, i-LnkMed ibilokhu igxile emkhakheni wama-injectors anamandla aphezulu okucindezela. Ithimba lobunjiniyela le-LnkMed liholwa yi-Ph.D. elinolwazi olungaphezu kweminyaka eyishumi futhi lihileleke kakhulu ocwaningweni nasekuthuthukisweni. Ngaphansi kwesiqondiso sakhe, i-Umjovo wekhanda elilodwa le-CT,Umjovo wekhanda eliphindwe kabili we-CT,Umjovo we-MRI contrast agent, futhiI-Angiography high-pressure contrast agent injector injectorzenzelwe lezi zici: umzimba oqinile futhi ohlangene, isikhombimsebenzisi sokusebenza esilula nesihlakaniphile, imisebenzi ephelele, ukuphepha okuphezulu, kanye nomklamo ohlala isikhathi eside. Singaphinde sinikeze amasirinji namashubhu ahambisana nalawo mabhrendi adumile e-CT, MRI, DSA injectors Ngenxa yesimo sabo sengqondo esiqotho kanye namandla ochwepheshe, bonke abasebenzi be-LnkMed bakumema ngobuqotho ukuthi nize nizohlola izimakethe ezengeziwe ndawonye.